Category Archives: Cancer in the news

Device delivers toxic chemo cocktail to pancan tumor, spares body

Researchers have found a way to hit pancreatic cancer hard with a drug-delivery device that puts a lethal combination of four chemo drugs directly into the tumor while limiting the impact on the rest of the body.

Pancreatic cancer is a killer, and to attack a killer you sometimes need to hit it with a highly toxic drug cocktail. However, doing this through the bloodstream only works in a few patients because of the widespread damage to the rest of the body.

In the Proceedings of the National Academy of Sciences, the team from the University of North Carolina (UNC) at Chapel Hill describes how they tested the implantable “iontophoretic device” in mice.

The researchers found that using the iontophoretic device to deliver a particularly toxic mix of four chemotherapy drugs stopped pancreatic tumors in the mice from growing – and in some cases even shrank them – while sparing the rest of the body.

Senior author Jen Jen Yeh, an associate professor of surgery and pharmacology in the UNC School of Medicine, says:

“It’s an exciting approach because there is so little systemic toxicity that it leaves room to administer additional drugs against cancer cells that may have spread in the rest of the body.”

In their study, the team found that compared with intravenous delivery, the iontophoretic device “resulted in better tumor response and tolerability,” when used to attack pancreatic tumors in mice with FOLFIRINOX – a combination of the chemotherapy drugs folinic acid (leucovorin), fluorouracil, irinotecan and oxaliplatin.

Helping more patients qualify for surgery

FOLFIRINOX is a first-line treatment for pancreatic cancer and has been shown to halt or shrink tumors in nearly a third of patients. However, because it is so toxic to the rest of the body, there are many patients who cannot tolerate it when it is delivered through the bloodstream.

The implantable device uses an electric field to drive the chemotherapy drugs directly into the tumor.

The new study follows another published a year ago where the team showed the first successful use of the iontophoretic device in treating human pancreatic tumors grafted into mice and dogs.

Pancreatic cancer is the cause of 7% of all cancer deaths and ranks fourth as a cause of cancer death in both men and women every year in the US, where rates of the disease have been rising by 1.2% a year over the last 10 years.

Early stage pancreatic cancer usually has no symptoms and spreads quickly to the rest of the body, making it difficult to detect and harder to treat when it is found in its later stages.

Consequently, only one in four patients survive more than a year after diagnosis – a statistic that has not changed in over 40 years.

Surgery to remove the pancreatic tumor is currently the best chance of cure, but unfortunately only 15% of patients have operable tumors.

The hope is that the new device will halt and potentially shrink tumors so that more patients with localized and locally advanced pancreatic cancer qualify for surgery.

The team is planning to get the device into clinical trials in the next few years.

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*credit verbatim via Catharine Paddock PhD and http://www.medicalnewstoday.com *

Ginger May Be Stronger Than Chemo?

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Cancer is one of humankind’s greatest modern scourges. We subject ourselves to horrifically toxic treatments to try to stem its assault, but it still claims millions of victims every year. However, there are several studies that have shown that an all-natural remedy made of ginger root could be more effective against certain types of cancer than more harmful interventions like chemotherapy and radiation.

In 2007, the BMC Complementary and Alternative Medicine published a study that demonstrated ginger’s ability to combat ovarian cancer, which is the most deadly cancer of the female reproductive system, according to the American Cancer Society. The ginger works by blocking the cancer from growing, limiting its ability to spread.

“Ginger inhibits growth and modulates secretion of angiogenic factors in ovarian cancer cells,” the study states. “The use of dietary agents such as ginger may have potential in the treatment and prevention of ovarian cancer.”

Another study from the University of Michigan Comprehensive Cancer Center discovered an even more promising effect — ginger actually caused the death of ovarian cancer cells in a lab. The breakthrough could be truly groundbreaking, since cancer that is treated with chemo has a tendency to recur and can build up resistance to it over time. If ginger can kill the cancer outright, that’s a far better solution.

Then, a study published in the British Journal of Nutrition in 2012 found that ginger also shows extraordinary effects against prostrate cancer, which will afflict one in six men in the United States.

“Whole ginger extract (GE) exerts significant growth-inhibitory and death-inductory effects in a spectrum of prostate cancer cells,” the study states. “Comprehensive studies have confirmed that GE perturbed cell-cycle progression, impaired reproductive capacity, modulated cell-cycle and apoptosis regulatory molecules and induced a caspase-driven, mitochondrially mediated apoptosis in human prostate cancer cells.”

In other words, the ginger actually tricks the cancer cells into killing themselves. As a result, it shrank prostate tumors by an average of 56 percent.

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*credit verbatim via http://www.reset.me and Aaron Kase*

10 Cancer Clinical Trial Facts Every Patient Should Know

Extraordinary scientific advances have been made in the last few decades in the fight against cancer. Translating these breakthroughs into clinical progress will significantly impact treatment for cancer patients.

But how much progress we make depends largely on patients’ willingness to participate in clinical trials and physicians’ encouragement of clinical trials as a treatment option.

For pancreatic cancer, for example, there are few effective treatment options. This makes clinical trial participation for this cancer vital to the research in which scientists are seeking new and better treatments.

Lack of awareness of trials, and low prioritization of clinical trials by physicians and patients facing cancer, contribute to low enrollment rates. Whether they’re reluctant to participate or unaware of the opportunities, physicians and cancer patients should not ignore clinical trials. People who are willing to be a part of this process will help us find new diagnostics and treatment options — for themselves and other cancer patients.

Here are 10 things you might not know about clinical trials:

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*credit verbatim via everydayhealth.com and Lynn Matrisian, PhD, MBA, is vice president of scientific and medical affairs at the Pancreatic Cancer Action Network*

Foods That Kill Cancer

*credit verbatim via Michael Edwards, Epoch Times*

In order to defeat cancer and ensure there is no recurrence, the body must be brought into balance and the immune system rebuilt and fine tuned. So how is this feat accomplished? Detox, detox, detox and achieve a slightly alkaline pH, while filling the body with the best, organic, nutritionally dense food available. Your goal is to rebuild a killer immune system as you bathe every non-cancerous cell in your body with nutrition.

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*credit verbatim via Michael Edwards, Epoch Times*

Scientists Detect Early Sign of Pancreatic Cancer

*credit verbatim via CBSNews.com*

Researchers say they’ve identified a sign of early development of pancreatic cancer, a leading cause of cancer death. And, they add, their discovery might lead one day to a new test to detect the disease in its initial and more treatable stages…

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